1173898-33-3Relevant academic research and scientific papers
Intramolecular C(sp3)–H Bond Oxygenation by Transition-Metal Acylnitrenoids
Chen, Shuming,Hong, Yubiao,Houk, K. N.,Ivlev, Sergei,Meggers, Eric,Tan, Yuqi,Zhou, Zijun
, p. 21706 - 21710 (2020/10/02)
This study demonstrates for the first time that easily accessible transition-metal acylnitrenoids can be used for controlled direct C(sp3)-H oxygenations. Specifically, a ruthenium catalyst activates N-benzoyloxycarbamates as nitrene precursors towards regioselective intramolecular C?H oxygenations to provide cyclic carbonates, hydroxylated carbamates, or 1,2-diols. The method can be applied to the chemoselective C?H oxygenation of benzylic, allylic, and propargylic C(sp3)?H bonds. The reaction can be performed in an enantioselective fashion and switched in a catalyst-controlled fashion between C?H oxygenation and C?H amination. This work provides a new reaction mode for the regiocontrolled and stereocontrolled conversion of C(sp3)-H into C(sp3)?O bonds.
Synthesis of α-hydroxyallenes by copper-catalyzed S N2′substitution of propargylic dioxolanones
Tang, Xiaoping,Woodward, Simon,Krause, Norbert
experimental part, p. 2836 - 2844 (2009/09/29)
A new catalytic method for the synthesis of α-hydroxyallenes is described. Efficient SN2′ substitution of propargylic dioxolanones has been achieved with a copper(I)/P(OBu)3 catalyst: using Grignard reagents as the nucleophiles. The
