1173898-55-9

Basic information

• Product Name: 1-allyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)piperidin-4-yl)-3-(4-(trifluoromethyl)benzyl)urea
• CAS NO: 1173898-55-9
• Molecular Weight: 630.726
• Mol File: 1173898-55-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-allyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)piperidin-4-yl)-3-(4-(trifluoromethyl)benzyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-allyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)piperidin-4-yl)-3-(4-(trifluoromethyl)benzyl)urea(1173898-55-9)
• EPA Substance Registry System: 1-allyl-1-(1-(((3S,4R)-1-(cyclopentanecarbonyl)-4-(3-fluorophenyl)-4-hydroxypyrrolidin-3-yl)methyl)piperidin-4-yl)-3-(4-(trifluoromethyl)benzyl)urea(1173898-55-9)

Safety Data

• Hazardous Substances Data: 1173898-55-9(Hazardous Substances Data)

Upstream product

• 1173898-79-7 C₁₇H₂₀FNO₃ 
• 1272006-62-8 C₁₇H₂₂F₃N₃O 

Relevant articles and documents

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents

Modification of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists revealed that introducing a fluoro group at the 3-position of the 3-phenyl group to reduce metabolism did not adversely affect the high potency against HIV infection, and that replacing the piperidine ring with a tropane ring could deliver the most potent anti-HIV agents. Stereochemistry of the substituted tropane ring is essential for maintaining the potent anti-HIV activity because only exo-isomers displayed subnanomolar whole cell activity.