1173910-98-9Relevant academic research and scientific papers
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
Walker, Daniel P.,Zawistoski, Michael P.,McGlynn, Molly A.,Li, Jian-Cheng,Kung, Daniel W.,Bonnette, Peter C.,Baumann, Amy,Buckbinder, Leonard,Houser, Janet A.,Boer, Jason,Mistry, Anil,Han, Seungil,Guzman-Perez, Li Xing and Angel
scheme or table, p. 3253 - 3258 (2010/03/31)
The synthesis, in vitro properties, and in vivo pharmacokinetics for a series of sulfoximine-substituted trifluoromethylpyrimidines as inhibitors of proline-rich tyrosine kinase, a target for the possible treatment of osteoporosis, are described. These co
