1173932-39-2Relevant academic research and scientific papers
Synthesis of the new ring system 2-oxo-[1,4]oxazino[3,2-e]indole, heteroanalogue of Angelicin
Barraja, Paola,Diana, Patrizia,Montalbano, Alessandra,Martorana, Annamaria,Carbone, Anna,Cirrincione, Girolamo
scheme or table, p. 4182 - 4184 (2009/12/01)
A convenient synthesis of the 2-oxo-[1,4]oxazino[3,2-e]indole ring system, an heteroanalogue of Angelicin, is reported. Our synthetic approach consisted of the annelation of the oxazine ring on the indole moiety using 4-amino-5-hydroxy indoles as building blocks. The antiproliferative activity of the new compounds either in the dark or under UVA irradiation was investigated.
