1173977-35-9

Upstream product

• 10130-74-2 m-Methoxybenzenesulfonyl chloride 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 1173977-36-0 [(4-Chlorophenyl)-(3-methoxy-benzenesulphonyl)-amino]-acetic acid methyl ester 
• 1082398-63-7 C₁₂H₁₀ClNO₃S 
• 1531587-74-2 C₂₃H₂₀ClN₃O₅S 

Relevant academic research and scientific papers

Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c] pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists

The discovery and optimization of novel N-(3-(1,3-dioxo-2,3-dihydro-1H- pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamide GPR119 agonists is described. Modification of the pyridylphthalimide motif of the molecule with R1 =-Me and R2 =-iPr substituents, incorporated with a 6-fluoro substitution on the central phenyl ring offered a potent and metabolically stable tool compound 22.

SULFONAMIDES AS OREXIN ANTAGONISTS

The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3 and n are as described in the description and claims. The compounds are orexin receptor antagonists, useful in the treatment of disor

BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS

There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.