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6,7-O-Demethylen-epipodophyllotoxin is a semi-synthetic derivative of the naturally occurring compound epipodophyllotoxin, which is extracted from the roots and rhizomes of the mayapple plant (Podophyllum peltatum). This chemical is characterized by the removal of two methyl groups from the parent compound, specifically from the 6 and 7 positions, and the introduction of a double bond between these positions. It is known for its potent anti-cancer properties, as it inhibits the enzyme topoisomerase II, which is crucial for DNA replication. This inhibition leads to the prevention of cancer cell division and ultimately cell death. The compound serves as a key intermediate in the synthesis of several chemotherapeutic drugs, including etoposide, teniposide, and etopophos, which are used in the treatment of various types of cancer. The development and use of 6,7-O-Demethylen-epipodophyllotoxin and its derivatives have significantly contributed to advancements in cancer therapy.

1174-96-5

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1174-96-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1174-96-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,7 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1174-96:
(6*1)+(5*1)+(4*7)+(3*4)+(2*9)+(1*6)=75
75 % 10 = 5
So 1174-96-5 is a valid CAS Registry Number.

1174-96-5Downstream Products

1174-96-5Relevant academic research and scientific papers

Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring

Castro, Angeles,Del Corral, Jose M. Miguel,Gordaliza, Marina,Grande, Concepcion,Gomez-Zurita, Antonia,Garcia-Gravalos, Dolores,San Feliciano, Arturo

, p. 65 - 74 (2003)

Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549,

In vivo immunosuppressive activity of some cyclolignans

Gordaliza, Marina,Castro, M. Angeles,Miguel del Corral, Jose M.,Lopez-Vazquez, M. Luisa,San Feliciano, Arturo,Faircloth, Glynn T.

, p. 2781 - 2786 (2007/10/03)

Several podophyllotoxin-related cyclolignans, either lacking the lactone ring or the methylenedioxy grouping, have been prepared and evaluated for their immunosuppressive (IMS) activity in the mouse allogeneic MLR in vitro test and in the in vivo techniqu

Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents

Terada,Fujimoto,Nomura,Yamashita,Kobunai,Takeda,Wierzba,Yamada,Yamaguchi

, p. 2720 - 2727 (2007/10/02)

Various podophyllotoxin derivatives from desoxypodophyllotoxin (DPT) were synthesized to examine the structural relationships between the biological significance (cytotoxic effect, effects on DNA topoisomerase II and tubulin polymerization) in vitro and a

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