1174005-78-7

Usage

Organic compound

Derived from indole and carboxaldehyde This refers to the fact that 1H-Indole-3,7-dicarboxaldehyde is a carbon-based compound formed by combining indole and carboxaldehyde.

Intermediate in synthesis

Used in the synthesis of various pharmaceuticals and agrochemicals 1H-Indole-3,7-dicarboxaldehyde serves as a starting material or building block in the production of a variety of drugs and chemicals used in agriculture.

Biological activities

Anti-cancer, anti-bacterial, and anti-inflammatory properties These are some of the therapeutic effects that 1H-Indole-3,7-dicarboxaldehyde has been found to exhibit, making it a potential candidate for the development of new treatments for various diseases.

Potential applications

Fluorescent dyes and enzyme inhibitors 1H-Indole-3,7-dicarboxaldehyde has been studied for its possible use in creating fluorescent dyes and as a compound that can inhibit the activity of enzymes involved in diseases such as diabetes and Alzheimer's.

Importance in chemistry

Medicinal and pharmaceutical chemistry Due to its diverse properties and potential applications, 1H-Indole-3,7-dicarboxaldehyde is considered an important compound in the fields of medicinal and pharmaceutical chemistry.

Upstream product

• 53951-34-1 o-nitrobenzaldehyde dibutyl acetal 
• 552-89-6 2-nitro-benzaldehyde 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Hetero-triarylmethanes from Racemic Indolyl Alcohols

The direct enantioselective 1,4- and 1,8-arylations of 7-methide-7H-indoles and 6-methide-6H-indoles, respectively, generated in situ from diarylmethanols, with electron-rich arenes as nucleophiles, has been achieved in the presence of chiral phosphoric acids (CPAs). These two remote activation protocols provide an efficient approach for the construction of diverse hetero-triarylmethanes in high yields (up to 97 %) and with excellent enantioselectivities (up to 96 %). Mechanistically inspired experiments tentatively indicate that the catalytic enantioselective 1,4-addition as well as the formal SN1 substitution could proceed efficiently in the similar catalytic systems. Furthermore, the modification of the catalytic system and diarylmethanol structure successfully deviates the reactivity toward a remote, highly enantioselective 1,8-arylation reaction. This flexible activation mode and novel reactivity of diarylmethanols expand the synthetic potential of chiral phosphoric acids.

Aminocatalyzed Cascade Synthesis of Enantioenriched 1,7-Annulated Indoles from Indole-7-Carbaldehyde Derivatives and α,β-Unsaturated Aldehydes

We report herein a new cascade strategy for the enantioselective synthesis of 1,7-annulated indoles based on iminium-enamine activation. A careful study of the indole substitution pattern revealed that a chloro substituent at the C-3 position was importan