1174020-24-6Relevant articles and documents
Practical and cost-effective manufacturing route for the synthesis of a β-lactamase inhibitor
Miller, Steven P.,Zhong, Yong-Li,Liu, Zhijian,Simeone, Michael,Yasuda, Nobuyoshi,Limanto, John,Chen, Zheng,Lynch, Joseph,Capodanno, Vincent
, p. 174 - 177 (2014/01/23)
Compound 1, a potent and irreversible inhibitor of β-lactamases, is in clinical trials with β-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.