1174020-42-8

Basic information

• Product Name: tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate
• Synonyms: tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate;(3R,4S)-1-Boc-3-fluoro-4-hydroxypiperidine;(3R,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate;tert-Butyl(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate>98%ee;(3R,4S)-3-Fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;9942-2b-2;1-Piperidinecarboxylic acid, 3-fluoro-4-hydroxy-, 1,1-dimethylethyl ester, (3R,4S)-
• CAS NO: 1174020-42-8
• Molecular Formula: C₁₀H₁₈FNO₃
• Molecular Weight: 219
• Mol File: 1174020-42-8.mol

Chemical Properties

• Boiling Point: 300.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.65±0.40(Predicted)
• CAS DataBase Reference: tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate(1174020-42-8)
• EPA Substance Registry System: tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate(1174020-42-8)

Safety Data

• Hazardous Substances Data: 1174020-42-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate is used as an intermediate in the synthesis of pharmaceuticals for its ability to modify biological activity. tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate's unique structure allows it to be a versatile building block in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate is used as an intermediate in the synthesis of various agrochemicals, contributing to the development of effective and stable products for agricultural applications.
Used in Organic Compounds Synthesis:
Tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate is utilized as an intermediate in the synthesis of other organic compounds, showcasing its versatility in chemical research and development.
Used in Chemical Research and Development:
tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate is employed in chemical research and development due to its diverse potential uses, including the exploration of new chemical reactions and the creation of novel molecules with specific properties.

Upstream product

• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 
• 1266339-10-9 tert-butyl (3R)-3-fluoro-4-oxopiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 955029-44-4 (anti)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 1208864-35-0 tert-butyl 3-fluoro-4,4-dihydroxypiperidin-1-carboxylic acid 
• 955029-44-4 (syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 211108-48-4 tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate 
• 955029-44-4 (syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1450879-65-8 tert-butyl (3R,4S)-3-fluoro-4-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate 

Relevant articles and documents

Efforts towards a Noyori reduction of a 3-fluorpiperidin-4-one with dynamic kinetic resolution

A Noyori reduction of racemic 1-Boc-3-fluoropiperidin-4-one has been achieved under dynamic kinetic resolution conditions that results in a single cis enantiomer being obtained with both diastereo- and enantioselectivity > 90%. This medicinal chemistry building block can be generated on multi-gram scale using the developed conditions to a single enantiomer in a 60% yield after employing a crystallisation procedure.

Enantioselective synthesis of cis -3-fluoropiperidin-4-ol, a Building block for medicinal chemistry

The first enantioselective route to both enantiomers of cis-1-Boc-3-fluoropiperidin-4-ol, a highly prized building block for medicinal chemistry, is reported. An enantioselective fluorination is employed, taking advantage of the methodology reported by MacMillan, which uses a modified cinchona alkaloid catalyst. In studying the fluorination reaction, we have shown that the catalyst can be replaced by commercially available primary amines, including α-methylbenzylamine, with similar levels of enantioselectivity. The piperidinols are readily crystallized to obtain enantiopure material.

GPR 119 MODULATORS

Compounds that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein- coupled receptor GPR119 in animals are described herein.

4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS

Compounds that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein- coupled receptor GPR119 in animals are described herein.

IMIDAZO-PYRAZOLES AS GPR119 INHIBITORS

Compounds of formula (I) wherein: X is (A) or (B); Y is O or a bond; R1 is -C(O)-O-R3 or R2 is hydrogen, cyano, C1-C6 alkyl, or C3-C6 cycloalkyl; R5 is hydrogen, cyano

GPR 119 MODULATORS

Compounds of formula (I) that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.

GPR 119 MODULATORS

Compounds of Formula (I) that modulate the activity of the G -protein-coupled receptor GPFM 19 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.