1174027-16-7Relevant articles and documents
Liposomes containing alkylated methotrexate analogues for phospholipase A2 mediated tumor targeted drug delivery
Kaasgaard, Thomas,Andresen, Thomas L.,Jensen, Simon S.,Holte, Rene O.,Jensen, Lotte T.,Jorgensen, Kent
, p. 94 - 103 (2009)
Two lipophilic methotrexate analogues have been synthesized and evaluated for cytotoxicity against KATO III and HT-29 human colon cancer cells. Both analogues contained a C16-alkyl chain attached to the γ-carboxylic acid and one of the analogue