1174028-89-7Relevant articles and documents
Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator
Ritzen, Andreas,Sindet, Rikke,Hentzer, Morten,Svendsen, Nannette,Brodbeck, Robbin M.,Bundgaard, Christoffer
supporting information; experimental part, p. 3275 - 3278 (2010/03/24)
This Letter describes the discovery of a novel series of mGluR5 positive allosteric modulators (PAMs). The lead compound, 11c, exhibits excellent potency (EC50 = 30 nM) in vitro, and reaches high brain levels in both rats and mice after oral ad