1174038-67-5

Basic information

• Product Name: tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
• Synonyms: tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate;tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate;1-N-Boc-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrrolo[2,3-c]pyridine;tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-c]pyridine-1-carboxylate;1-Boc-6-Azaindole-3-boronic acid pinacol ester
• CAS NO: 1174038-67-5
• Molecular Formula: C18H25BN2O4
• Molecular Weight: 344.22
• Mol File: 1174038-67-5.mol

Chemical Properties

• Melting Point: 114-124 °C
• Boiling Point: 470.1±48.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.20±0.30(Predicted)
• CAS DataBase Reference: tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate(1174038-67-5)
• EPA Substance Registry System: tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate(1174038-67-5)

Safety Data

• Hazardous Substances Data: 1174038-67-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate is used as a reagent for the preparation of pyrrolo[2,3-c]pyridinylpyrimidinylamines. These compounds are of significant interest due to their potential as antitumor agents, making this reagent a valuable tool in the development of novel cancer treatments.
Application Reason:
The unique chemical structure of tert-butyl 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate allows it to participate in various chemical reactions, particularly in the synthesis of biologically active molecules. Its use in the preparation of pyrrolo[2,3-c]pyridinylpyrimidinylamines highlights its potential in contributing to the advancement of cancer research and therapeutics.

Upstream product

• 370880-82-3 tert-butyl 1H-pyrrolo [2,3-c]pyridine-1-carboxylate 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 1174038-59-5 tert-butyl 3-iodo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 74420-15-8 3-bromo-1H-pyrrolo[2,3-b]pyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES

Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumours

Boc groups as protectors and directors for ir-catalyzed C-H borylation of heterocycles

(Chemical Equation Presented) Ir-catalyzed C-H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C-H positions β to N. The Boc group can be removed on thermolysis