1174039-95-2

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 
• 615-43-0 2-iodophenylamine 
• 253435-24-4 2-(2-(4-(methyl)phenyl)ethynyl)benzonitrile 
• 4387-36-4 2-iodobenzonitrile 
• 189008-33-1 2-[2-(4-methylphenyl)ethynyl]benzaldehyde 
• 873-32-5 2-Chlorobenzonitrile 
• 95-51-2 o-chloroaniline 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 

Relevant academic research and scientific papers

Rhodium-Catalyzed Annulation of 2-Arylimidazoles and α-Aroyl Sulfoxonium Ylides toward 5-Arylimidazo[2,1- a ]isoquinolines

A Rh-catalyzed annulation between 2-aryl-1 -benzo[ d ]imidazoles and α-aroyl sulfoxonium ylides was developed, affording a series of benzimidazo[2,1- a ]isoquinolines in moderate to excellent yields. This procedure proceeded with the sequential ortho C-H functionalization and cyclization, representing a facile and straightforward pathway to access such frameworks.

In situ air oxidation and photophysical studies of isoquinoline-fused N-heteroacenes

An efficient, metal free and environment friendly synthesis of isoquinoline-fused benzimidazole has been developed via in situ air oxidation. Also, syntheses of isoquinoline-fused quinazolinone heteroacenes were successfully achieved. The synthesized isoquinoline-fused benzimidazole and isoquinoline-fused quinazolinone derivatives showed λmax, Fmax and Φf values in the ranges 356-394 nm, 403-444 nm and 0.063-0.471, respectively, in CHCl3,.

Nickel-Catalyzed Annulation of o-Haloarylamidines with Aryl Acetylenes: Synthesis of Isoquinolone and 1-Aminoisoquinoline Derivatives

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamidines with aryl alkynes in the presence of water is described. Benzo[4,5]imidazo[2,1-a]isoquinolines were formed as the dominated products when dry dimethyl sulfoxide was used as the solvent. Furthermore, when benzyl substituted amidines were used as the substrates, debenzylation reaction occured to provide various 1-aminoisoquinoline products. (Figure presented.).

Selective synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines via copper-catalyzed tandem annulation of alkynylbenzonitriles with 2-Iodoanilines

An efficient copper-catalyzed cascade cyclization reaction for selectively synthesizing a variety of benzo[4,5]imidazo[2,1-a]isoquinoline derivatives has been developed. The reaction features the formation of three different C–N bonds in sequence. In the

Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium- catalyzed intramolecular C-H vinylation: Synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines

An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.

One-pot concise syntheses of benzimidazo[2,1-a]isoquinolines by a microwave-accelerated tandem process

Direct, efficient syntheses of the benzimidazo[2,1-a]isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1,2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation.