1174046-72-0 Usage
Uses
BMS-794833 is a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor and it also inhibits Ron (Met family),Axl and Flt-3 with IC50 values <3 nM.
Biological Activity
bms-794833 is a potent atp competitive, dual inhibitor of c-met and vegfr2 (ic50 = 1.7 nm and 15 nm, respectively). it also has inhibitory effect on ron, axl and flt3 (ic50 < 3 nm).c-met, also called met, is a membrane receptor that is essential for embryonic development and wound healing. vegfr are receptors for vascular endothelial growth factor and belong to receptor tyrosine kinases. it mediates in various cellular functions, including endothelial proliferation, migration, survival, tubular morphogenesis and sprouting. [1]bms794833 also inhibited gastric cancer cell line (gtl-16) that induced by c-met receptor, gtl-16, ic50 = 39 nm [1]. in human gastric tumor xenografts model, bm798433 exhibits > 50% tgi for at least one tumor doubling time without significant toxicity in 14 days. in u87 glioblastoma model, 25mg/kg of bms798433 exert complete tumor stasis. [1]
references
[1] 4-pyridinone compounds and their use of cancer, borzilleri et al, united states patent application publication, pub no. : us 2012/0114643 a1, pub.date: may 10, 2012.
Check Digit Verification of cas no
The CAS Registry Mumber 1174046-72-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,4,0,4 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1174046-72:
(9*1)+(8*1)+(7*7)+(6*4)+(5*0)+(4*4)+(3*6)+(2*7)+(1*2)=140
140 % 10 = 0
So 1174046-72-0 is a valid CAS Registry Number.
1174046-72-0Relevant articles and documents
4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER
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Page/Page column 27; 37, (2009/09/05)
Disclosed are compounds of Formula (I)and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a