1174065-46-3Relevant academic research and scientific papers
Halogenated 4-aryloxymethylcoumarins as potent antimicrobial agents
Shivashankar,Shastri, Lokesh A.,Kulkarni, Manohar V.,Rasal, Vijaykumar P.,Saindane, Deepak M.
experimental part, p. 1163 - 1168 (2009/12/25)
Halogenated phenols reacted with various 4-bromomethylcoumarins to furnish the corresponding 4-aryloxymethylcoumarins. Introduction of chloro and methoxy groups in the coumarin ring elicited considerable antimicrobial activity against B. subtilis, E. coli, A. niger and C. albicans. In the aryloxy moiety, the chloro group as a substituent were found to be more active than the corresponding bromo compounds. The growth inhibition was observed even at concentrations of less than 10 μg ml-1 in some cases.
