117409-05-9

Upstream product

• 100-70-9 2-Cyanopyridine 
• 46032-98-8 (1R,2R)-2-amino-1-phenylpropane-1,3-diol 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 19547-38-7 methyl pyridine-2-imidate 

Downstream Products

• 127490-02-2 (E)-3-Phenyl-acrylic acid (4R,5R)-5-phenyl-2-pyridin-2-yl-4,5-dihydro-oxazol-4-ylmethyl ester 
• 127490-00-0 (4S,5S)-4-(trityloxy-methyl)-5-phenyl-2-(2-pyridinyl)-1,3-oxazoline 
• 117409-06-0 (3'S,4'S)-2-(3',4'-dihydro-3'-phenyl-4'-methyloxy-methyl-2'-oxazolyl)pyridine 
• 127489-99-0 2-[(4R,5R)-4-(2,6-Dimethoxy-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine 
• 127489-98-9 2-[(4R,5R)-4-(2,6-Dimethyl-phenoxymethyl)-5-phenyl-4,5-dihydro-oxazol-2-yl]-pyridine 
• 127490-05-5 C₂₀H₁₇N₃O₂ 
• 127490-01-1 1-((4R,5R)-5-Phenyl-2-pyridin-2-yl-4,5-dihydro-oxazol-4-ylmethyl)-1H-pyridin-2-one 
• 127490-04-4 2-((4S,5R)-5-Phenyl-4-phenylsulfanylmethyl-4,5-dihydro-oxazol-2-yl)-pyridine 
• 127489-97-8 2-((4R,5R)-4-Phenoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-pyridine 
• 117409-06-0 2-((4R,5R)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-pyridine 
• 127503-12-2 Methanesulfonic acid (4R,5R)-5-phenyl-2-pyridin-2-yl-4,5-dihydro-oxazol-4-ylmethyl ester 

Relevant academic research and scientific papers

ENANTIOSELECTIVE HYDROSILYLATION OF ACETOPHENONE WITH RHODIUM /OXAZOLINES CATALYSTS

N-chelate ligands based on chiral oxazolines are efficient co-catalysts in the enantioselective hydrosilylation of acetophenone with α-naphtylphenylsilane.Enantiomeric excess as up to 80percent have been achieved.

Asymmetric Catalysis, 45. - Enantioselective Hydrosilylation of Ketones with 2/Pyridinyloxazoline Catalysts

21 optically active 2-(2-pyridinyl)oxazolines are synthesized from 2-cyanopyridine and optically pure amino alcohols.The new pyridinyloxazolines are used as cocatalysts together with 2 as homogeneous in situ catalysts in the enantioselective hydrosilylation of prochiral ketones with diphenylsilane.After hydrolysis, 1-phenylethanol is produced in 83.4percent ee from acetophenone.Another three ketones are included into these investigations.The optical purity depends on the rhodium/ligand, rhodium/ketone, and ketone/silane ratio as well as on the solvent.Compared with other organic solvents, hydrosilylations in the solvent CCl4 without exceptions result in better chemical yields and optical purities as consequence of a change in the catalytically active species due to oxidative addition of CCl4. - Keywords: Enantioselective hydrosilylation/ Optically active secondary alcohols/ Rhodium/ pyridinyloxazoline catalysts