1174147-50-2Relevant academic research and scientific papers
Stereoselective Intermolecular [4+2] Process of N,O-acetals with Terminal Alkynes for Construction of Functional cis-Pyrido and Pyrrolo[1,2-c][1,3]oxazin-1-ones
Wang, Chen,Mao, Zhuo-Ya,Liu, Yi-Wen,Wang, Qiao-E,Si, Chang-Mei,Wei, Bang-Guo,Lin, Guo-Qiang
, p. 822 - 831 (2020)
A diastereoselective approach to access cis-pyrido and pyrrolo[1,2-c][1,3]oxazin-1-ones has been developed through a one-pot BF3 .Et2O-catalyzed [4+2] process starting with N,O-acetals and terminal alkynes. In addition, the utility of this transformation is demonstrated by the scalable synthesis of (+)-Febrifugine in 7 steps from the N,O-acetal (15% overall yield). (Figure presented.).
BF3·Et2O catalyzed diastereoselective nucleophilic reactions of 3-silyloxypiperidine N,O-acetal with silyl enol ether and application to the asymmetric synthesis of (+)-febrifugine
Liu, Ru-Cheng,Huang, Wei,Ma, Jing-Yi,Wei, Bang-Guo,Lin, Guo-Qiang
body text, p. 4046 - 4049 (2009/10/11)
The asymmetric BF3·Et2O catalyzed nucleophilic reactions of 3-silyloxypiperidine N,O-acetal 10 with silyl enol ethers derived from ketones are described. (+)-Febrifugine 1, an antimalarial alkaloid, was successfully synthesized based
