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Propargyl-succinimidyl-ester, also known as N-Succinimidyl 3-(propargyloxy)propionate or Propargyl-N-hydroxysuccinimidyl ester, is an amine reactive reagent with acetylene and NHS ester functionalities. It is primarily used for derivatizing peptides, antibodies, and amine-coated surfaces. The alkyne group in Propargyl-succinimidyl-ester allows for reactions with azide-bearing compounds or biomolecules through copper-catalyzed Click Chemistry.

1174157-65-3

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1174157-65-3 Usage

Uses

Used in Chemical Synthesis:
Propargyl-succinimidyl-ester is used as a chemical reagent for the modification of amines, such as peptides and antibodies, to introduce new functional groups or tags for various applications.
Used in Bioconjugation:
Propargyl-succinimidyl-ester is used as a bioconjugation agent to attach biomolecules, like peptides or antibodies, to amine-coated surfaces or other amine-containing molecules, facilitating the development of new bioanalytical tools and techniques.
Used in Click Chemistry:
Propargyl-succinimidyl-ester is used as a key component in copper-catalyzed Click Chemistry reactions, enabling the selective and efficient formation of triazole linkages between alkyne and azide-bearing compounds or biomolecules.
Used in Chemoproteomics:
Propargyl-succinimidyl-ester is used as a tool for identifying nucleophilic ligandable hotspots in proteins by chemoproteomic approaches, which can be valuable for understanding protein function and developing targeted therapies.
Used in Drug Development:
Propargyl-succinimidyl-ester may be employed in the development of new drugs by modifying peptides or antibodies with specific functional groups, potentially enhancing their stability, specificity, or efficacy.
Used in Material Science:
Propargyl-succinimidyl-ester can be used in the modification of amine-coated surfaces or materials, allowing for the creation of new surface properties or the attachment of specific biomolecules for various applications, such as sensors or drug delivery systems.

Check Digit Verification of cas no

The CAS Registry Mumber 1174157-65-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,4,1,5 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1174157-65:
(9*1)+(8*1)+(7*7)+(6*4)+(5*1)+(4*5)+(3*7)+(2*6)+(1*5)=153
153 % 10 = 3
So 1174157-65-3 is a valid CAS Registry Number.

1174157-65-3 Well-known Company Product Price

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  • Aldrich

  • (764221)  Propargyl-N-hydroxysuccinimidyl ester  

  • 1174157-65-3

  • 764221-50MG

  • 789.75CNY

  • Detail
  • Aldrich

  • (764221)  Propargyl-N-hydroxysuccinimidyl ester  

  • 1174157-65-3

  • 764221-250MG

  • 2,961.27CNY

  • Detail

1174157-65-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name propargyl-NHS ester

1.2 Other means of identification

Product number -
Other names PROPARGYL-NHS 3-(PROP-2-YNYLOXY)PROPANOIC ACID SUCCINIMIDYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1174157-65-3 SDS

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