1174157-80-2Relevant academic research and scientific papers
Synthesis and peptide incorporation of an unnatural amino acid containing activity-based probe for protein tyrosine phosphatases
Shen, Kui,Qi, Lixin,Ravula, Mohini,Klimaszewski, Krzysztof
, p. 3264 - 3267 (2009)
An unnatural amino acid was synthesized to incorporate a quinone methide-generating activity-based probe for protein tyrosine phosphatases (PTPs) and then integrated into a PTP1B-specific substrate. The resulting probe led to preferential labeling of PTP1
Facile incorporation of a phosphatase activity-dependent quinone methide generating motif into phosphotyrosine
Shen, Kui,Qi, Lixin,Ravula, Mohini
experimental part, p. 3765 - 3768 (2010/06/12)
A novel phosphotyrosine analogue that incorporates a phosphatase activity-dependent quinone methide generating motif is synthesized from tyrosine. Following orthoformylation of the phenol moiety of methyl N-Cbz-tyrosinate, the Fmoc-protected 3-difluoromethyl analogue of phosphotyrosine is obtained by functional group transformations. Georg thieme Verlag Stuttgart.
