1174225-91-2

Upstream product

• 622-33-3 N-benzyloxyamine 
• 70932-71-7 3-methoxy-2-[2-(methoxycarbonyl)phenyl]-3-oxopropanoic acid 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 

Downstream Products

• 1383785-74-7 C₁₈H₁₅NO₅ 
• 1174226-00-6 methyl 2-(benzyloxy)-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate 
• 1383785-75-8 C₂₀H₁₉ClN₂O₄ 
• 1383786-02-4 N-phenyl-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-88-3 N-(3-chloro-4-methoxyphenyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-87-2 N-(3-fluorophenyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383786-06-8 N-(4-fluorophenyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383786-08-0 N-benzyl-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-90-7 C₂₅H₂₂N₂O₄ 
• 1383786-10-4 N-4-methoxybenzyl-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-91-8 N-(2,4-dimethoxybenzyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-92-9 N-(3,4-dimethoxybenzyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383785-89-4 C₂₄H₁₉FN₂O₄ 
• 1383786-13-7 N-(4-fluorophenethyl)-2-benzyloxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 

Relevant academic research and scientific papers

4-Substituted 2-hydroxyisoquinoline-1,3(2 H,4 H)-diones as a novel class of HIV-1 integrase inhibitors

A series of 2-hydroxy-1,3-dioxoisoquinoline-4-carboxamides featuring an N-hydroxyimide chelating functionality was evaluated for their inhibitory properties against human immunodeficiency virus type 1 integrase (HIV-1 IN). Several derivatives displayed low nanomolar IC50 values comparable to that of the clinically used raltegravir. A marked effect of one compound on both primary IN-catalyzed reactions, strand transfer (ST), and 3′ processing (3′-P), emphasizes a novel IN inhibition mechanism establishing it as a potential new generation IN inhibitor. Substitution of the 2-hydroxyisoquinoline-1,3-dione scaffold at position 4 by carboxamido chains was beneficial for antiviral activity since reproducible low micromolar anti-HIV activities were obtained for the first time within this scaffold.

2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS

The present invention relates to compounds and compositions acting as inhibitors of HIV integrase. The compound of the invention is of Formula (I), or a tautomer (I') thereof, or a pharmaceutically acceptable salt, or solvate of said compound or tautomer

Facile synthesis of 4-alkoxycarbonylisoquinoline-1,3-diones and 5-alkoxycarbonyl-2-benzazepine-1,3-diones via a mild alkaline cyclization

(Chemical Equation Presented) A series of 4-methoxycarbonylisoquinoline-1, 3-diones was obtained from homophthalic acid in four steps. The key step was the quantitative and rapid alkaline cyclization of 2-methoxycarbonyl-2-(2- methoxycarbonylphenyl) aceta