1174271-10-3

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 176910-67-1 2-(4-methoxyphenylethynyl)benzaldehyde 

Downstream Products

• 1174271-16-9 2,5-bis(4-methoxyphenyl)pyrazolo[5,1-a]isoquinoline 
• 1383274-34-7 N-(((4-bromo-3-(4-methoxyphenyl)isoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide 
• 1383274-35-8 N-(((4-bromo-3-(4-methoxyphenyl)isoquinolin-1-yl)(4-chlorophenyl)amino)(4-chlorophenylamino)methylene)-4-methylbenzenesulfonamide 
• 1221497-71-7 1-ethyl-5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinoline 
• 1400575-44-1 5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinoline 
• 1619916-64-1 N-benzyl-N-((5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinolin-2-yl)methyl)-4-methylbenzenesulfonamide 
• 1458688-27-1 1-(4-chlorophenyl)-5-(p-tolyl)-pyrazolo[5,1-a]isoquinoline 
• 1458688-18-0 5-(4-methoxyphenyl)-1-phenyl-pyrazolo[5,1-a]isoquinoline 
• 1420779-64-1 5-(4-methoxyphenyl)-2-methylpyrazolo[5,1-a]isoquinoline-1-carbaldehyde 
• 1415259-51-6 dimethyl 2-(5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinolin-1-yl)malonate 
• 1319204-99-3 N-(1-cyclopropyl-5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1200799-03-6 C₂₂H₁₇IN₂O₅ 
• 1200798-98-6 C₂₉H₂₅BrN₂O₇S 
• 1200798-92-0 C₂₉H₂₆N₂O₇S 

Relevant academic research and scientific papers

Synthesis of organoselenyl isoquinolinium imidesviairon(iii) chloride-mediated tandem cyclization/selenation ofN′-(2-alkynylbenzylidene)hydrazides and diselenides

This report describes the synthesis of organoselenyl isoquinolinium imides through a tandem cyclization betweenN′-(2-alkynylbenzylidene)hydrazides and diselenides. The reaction was carried out at room temperature under an ambient atmosphere using cheap iron(iii) chloride as the metallic source. The strategy shows good tolerance to a broad range ofN′-(2-alkynylbenzylidene)hydrazides and diselenides, and forms C-N and C-Se bonds in one step. The obtained product is further transformed into a bioactiveH-pyrazolo[5,1-a]isoquinoline skeleton easilyviaa silver catalyzed [3 + 2] cycloaddition.

Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

A multi-component reaction of 2-alkynylbenzaldehyde, 4- methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki-Miyaura coupling reaction, leading to the diverse 1-(isoquinolin-1-yl) guanidines.