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1174289-18-9

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1174289-18-9 Usage

Uses

9-(1,3-Dioxolan-2-ylmethyl)-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione is an isomer impurity in the synthesis of Doxofylline (D557100), a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1174289-18-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,4,2,8 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1174289-18:
(9*1)+(8*1)+(7*7)+(6*4)+(5*2)+(4*8)+(3*9)+(2*1)+(1*8)=169
169 % 10 = 9
So 1174289-18-9 is a valid CAS Registry Number.

1174289-18-9Downstream Products

1174289-18-9Relevant articles and documents

Preparation method of doxofylline impurity A

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, (2021/07/01)

The invention relates to the field of medicinal chemistry, and provides a preparation method of a doxofylline impurity A aiming at the problems that the doxofylline impurity A can only be obtained by adopting an extraction method and the yield of the obtained product is low. The preparation method comprises the following steps: S1, carrying out condensation reaction on 1, 3-dimethyl-6-halogenated uracil and aminoacetaldehyde glycol in a solvent to obtain a compound III; S2, under the action of acid, carrying out nitrosation reaction on the compound III and a nitrosation reagent in a polar solvent to obtain a compound IV; S3, under the action of a catalyst, reducing the compound IV in a polar solvent through a reducing agent to obtain a compound V; S4, performing cyclization on the compound V and a cyclization reagent under the catalytic action of organic acid to obtain a compound VI; and S5, under the catalytic action of organic acid, carrying out an acetal exchange reaction on the compound VI and ethylene glycol to obtain the doxofylline impurity A. The preparation method has the advantages of easily available preparation raw materials, simple preparation process, short preparation period and high yield.

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