1174289-18-9Relevant articles and documents
Preparation method of doxofylline impurity A
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, (2021/07/01)
The invention relates to the field of medicinal chemistry, and provides a preparation method of a doxofylline impurity A aiming at the problems that the doxofylline impurity A can only be obtained by adopting an extraction method and the yield of the obtained product is low. The preparation method comprises the following steps: S1, carrying out condensation reaction on 1, 3-dimethyl-6-halogenated uracil and aminoacetaldehyde glycol in a solvent to obtain a compound III; S2, under the action of acid, carrying out nitrosation reaction on the compound III and a nitrosation reagent in a polar solvent to obtain a compound IV; S3, under the action of a catalyst, reducing the compound IV in a polar solvent through a reducing agent to obtain a compound V; S4, performing cyclization on the compound V and a cyclization reagent under the catalytic action of organic acid to obtain a compound VI; and S5, under the catalytic action of organic acid, carrying out an acetal exchange reaction on the compound VI and ethylene glycol to obtain the doxofylline impurity A. The preparation method has the advantages of easily available preparation raw materials, simple preparation process, short preparation period and high yield.