1174289-22-5

Basic information

• Product Name: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol
• Synonyms: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol;Bazedoxifene N-Oxide
• CAS NO: 1174289-22-5
• Molecular Formula: C30H34N2O4-
• Molecular Weight: 486.60196
• Product Categories: Aromatics;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 1174289-22-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol(1174289-22-5)
• EPA Substance Registry System: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol(1174289-22-5)

Safety Data

• Hazardous Substances Data: 1174289-22-5(Hazardous Substances Data)

Usage

Uses

Bazedoxifene N-Oxide is a metabolite of the selective estrogen receptor modulator, Bazedoxifene (B129250)

Upstream product

• 198481-32-2 bazedoxifene 

Relevant articles and documents

Preparation method of bazedoxifene oxide

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of bazedoxifene oxide, wherein the preparation method comprises the steps: by using bazedoxifene free alkali as a raw material, dissolving in a first benign solvent, adding an organic alkali, and adding a silane protecting group to protect two phenolic hydroxyl groups, and thus obtaining anintermediate 1; dissolving the intermediate 1 in a second benign solvent, and adding an oxidant for oxidation to obtain an intermediate 2; and dissolving the intermediate 2 in a third benign solvent,and adding a protecting group removing reagent to remove two molecular silane protecting groups, and thus obtaining the bazedoxifene oxide. According to the preparation method of the bazedoxifene oxide provided by the invention, a preparation method of 1-[4-[2-(azacycloheptan-1-yl)ethoxy]benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indole-5-phenol-N-oxide is provided, and the preparation method has important significance in effectively controlling the quality of bazedoxifene.