1174295-54-5

Basic information

• Product Name: C₂₂H₂₈F₂O₇S
• Synonyms: C₂₂H₂₈F₂O₇S
• CAS NO: 1174295-54-5
• Molecular Weight: 474.523
• Mol File: 1174295-54-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₈F₂O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₈F₂O₇S(1174295-54-5)
• EPA Substance Registry System: C₂₂H₂₈F₂O₇S(1174295-54-5)

Safety Data

• Hazardous Substances Data: 1174295-54-5(Hazardous Substances Data)

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 1174295-62-5 2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-3,5-difluorobenzene-1-sulfonyl chloride 

Downstream Products

• 637-59-2 1-Bromo-3-phenylpropane 

Relevant articles and documents

Nucleophile assisting leaving groups: A strategy for aliphatic 18F-fluorination

(Chemical Equation Presented) A series of arylsulfonate nucleophile assisting leaving groups (NALGs) were prepared in which the metal chelating unit is attached to the aryl ring via an ether linker. TheseNALGs exhibited significant rate enhancements in halogenation reactions using metal halides. Studies with a NALG containing a macrocyclic ether unit suggest that rate enhancements of these nucleophilic halogenation reactions are facilitated by stabilization of charge in the transition state rather than through strong precomplexation with metal cation. In several cases, a primary substrate containing one of the new leaving groups rivaled or surpassed the reactivity of triflates when exposed to nucleophile but was otherwise highly stable and isolable. These and previously disclosed chelating leaving groups were used in 18F-fluorination reactions using no-carrier-added [ 18F]fluoride ion (t1/2 = 109.7 min, β+ = 97%) in CH3CN. Under microwave irradiation and without the assistance of a cryptand, such as K2.2.2, primary substrates with select NALGs led to a substantial improvement (2-3-fold) in radiofluorination yields over traditional leaving groups.