1174302-48-7

Upstream product

• 17195-27-6 N-hydroxy-glutarimide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1220888-78-7 N-{3 (benzylaminocarbonyl)propyl}-N'-benzyl urea 
• 121751-70-0 1-phenoxycarbonyl-2-oxopyrrolidine 
• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 1428524-83-7 4-({[(4-chlorobenzyl)oxy]carbonyl}amino)butanoic acid 
• 63216-41-1 4-({[(4-methoxybenzyl)oxy]carbonyl}amino)butanoic acid 
• 869541-05-9 γ-(benzyloxycarbonylamino)butanoic acid benzyl ester 

Relevant academic research and scientific papers

Studies on the Lossen-type rearrangement of N-(3-phenylpropionyloxy) phthalimide and N-tosyloxy derivatives with several nucleophiles

The reaction of N-(3-phenylpropionyloxy)phthalimide (1a) and N-tosyloxy (5a,b) derivatives with nucleophiles was examined and found to give the products via Lossen-type rearrangement. In order to obtain the scope of this reaction mechanism, further studies the reaction of several N-sulfonyloxyimide derivatives with various nucleophiles under similar conditions were carried out and found to afford the corresponding same types of products in high yields.

One-pot efficient synthesis of N α-urethane-protected β- And γ-amino acids

1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy] piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N α- urethane-protected β-alanine and γ-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.