1174309-16-0

Basic information

• Product Name: 1-(difluoromethyl)-1h-pyrazol-4-amine
• Synonyms: 1-(difluoromethyl)-1h-pyrazol-4-amine
• CAS NO: 1174309-16-0
• Molecular Formula: C4H5F2N3
• Molecular Weight: 133.0994064
• Mol File: 1174309-16-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 214.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• PKA: 2.59±0.15(Predicted)
• CAS DataBase Reference: 1-(difluoromethyl)-1h-pyrazol-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(difluoromethyl)-1h-pyrazol-4-amine(1174309-16-0)
• EPA Substance Registry System: 1-(difluoromethyl)-1h-pyrazol-4-amine(1174309-16-0)

Safety Data

• Hazardous Substances Data: 1174309-16-0(Hazardous Substances Data)

Usage

General Description

1-(Difluoromethyl)-1H-pyrazol-4-amine is a chemical compound with the molecular formula C4H5F2N3. It is a pyrazole derivative with a difluoromethyl group attached to the nitrogen atom. 1-(difluoromethyl)-1h-pyrazol-4-amine has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceutical drugs. It may also have uses in chemical research and synthesis. The presence of the difluoromethyl group in the compound may impart specific properties and reactivity, making it of interest to researchers in various scientific disciplines. Further study and exploration of the chemical properties and applications of 1-(difluoromethyl)-1H-pyrazol-4-amine may lead to its development and utilization in various fields.

Upstream product

• 956477-64-8 1-(difluoromethyl)-4-nitro-1H-pyrazole 

Downstream Products

• 1566543-09-6 1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide 

Relevant articles and documents

Photochemical synthesis method of heteroarylamine compounds

The invention provides a photochemical synthesis method of heteroarylamine compounds. The photochemical synthesis method comprises the following steps: S1, mixing raw materials including heteroaryl nitro compounds, a solvent and a photocatalyst to obtain a mixture; and S2, carrying out a photocatalytic reduction reaction on the mixture under an illumination condition to obtain a product system containing the heteroarylamine compounds. According to the photochemical synthesis method, photocatalytic reduction of various different heteroaryl nitro compounds is achieved under the illumination condition, and the high-yield heteroaryl amine compounds are obtained. The photocatalyst is an existing common catalyst, has no strict requirements on equipment and is easy to recover, and the safety riskof the heteroarylamine compound and the catalyst cost are reduced. Any metal reagent and reducing agent do not need to be added in the whole reaction process of photocatalysis, the reaction conversion rate is high, and post-treatment is simple and easy to operate, so the method is safer and more environmentally friendly.

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.