1174322-66-7

Basic information

• Product Name: 5-cyclopropylpicolinic acid
• Synonyms: 5-cyclopropylpicolinic acid;2-Pyridinecarboxylic acid, 5-cyclopropyl-
• CAS NO: 1174322-66-7
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17326
• Mol File: 1174322-66-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-cyclopropylpicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyclopropylpicolinic acid(1174322-66-7)
• EPA Substance Registry System: 5-cyclopropylpicolinic acid(1174322-66-7)

Safety Data

• Hazardous Substances Data: 1174322-66-7(Hazardous Substances Data)

Usage

General Description

5-cyclopropylpicolinic acid is a chemical compound with the molecular formula C8H7NO2. It is a derivative of picolinic acid, which is an important building block in pharmaceuticals and agrochemicals. 5-cyclopropylpicolinic acid contains a cyclopropyl group attached to the pyridine ring, making it a potentially useful molecule for medicinal chemistry and drug development. It has been studied for its potential as a drug candidate for various diseases, including cancer and neurological disorders. 5-cyclopropylpicolinic acid has also demonstrated potential as a ligand for metal complexes in coordination chemistry. Its unique structural features make it a versatile and valuable molecule for further research and potential applications in various fields.

Upstream product

• 137178-88-2 5-bromopyridine-2-carbonyl chloride 
• 30766-11-1 5-bromoisonicotinic acid 
• 188052-14-4 5-bromopyridine-2-carboxylic acid benzyl ester 
• 1415898-72-4 methyl 5-cyclopropylpicolinate 
• 29682-15-3 methyl 5-bromopicolinate 
• 1174322-67-8 tert-butyl 5-cyclopropyl-pyridine-2-carboxylate 

Relevant articles and documents

Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.