117440-06-9Relevant academic research and scientific papers
FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: Direct access to functionalized 2-aryl-4 H -chromenes
He, Xinwei,Wang, Hui,Cai, Xiaoting,Li, Qianqian,Tao, Jiajia,Shang, Yongjia
, p. 7191 - 7202 (2018)
An efficient and concise procedure has been developed for the synthesis of functionalized 2-aryl-4H-chromenes based on a tandem reaction of propargylamines and benzoylacetonitriles/malononitriles in the presence of FeCl3 as an environmentally friendly promoter. This reaction involves a highly efficient tandem sequence consisting of 1,4-conjugate addition, 6-endo-dig cyclization, and oxidation. This protocol tolerates a variety of functional groups, thereby providing a practical and efficient method for the fabrication of 2-aryl-4H-chromene skeletons.
