1174406-46-2Relevant academic research and scientific papers
Synthesis of oligonucleotides containing 2′-deoxyguanosine adducts of nitropyrenes
Colis, Laureen C.,Chakraborti, Debasis,Hilario, Pablo,McCarty, Christopher,Basu, Ashis K.
experimental part, p. 67 - 77 (2009/05/30)
Two different approaches to synthesize oligonucleotides containing the 2′-deoxyguanosine adducts formed by nitropyrenes are described. A direct reaction of an unmodified oligonucleotide with an activated nitropyrene derivative is a convenient biomimetic approach for generating the major adducts in DNA. A total synthetic approach, by contrast, involves several synthetic steps, including Buchwald-Hartwig Pd-catalyzed coupling, but can be used for incorporating both the major and minor adducts in DNA in high yield. Copyright Taylor & Francis Group, LLC.
