1174427-20-3Relevant academic research and scientific papers
Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same
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, (2015/09/23)
Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
Access to poly-β-peptides with functionalized side chains and end groups via controlled ring-opening polymerization of β-lactams
Zhang, Jihua,Kissounko, Denis A.,Lee, Sarah E.,Gellman, Samuel H.,Stahl, Shannon S.
supporting information; experimental part, p. 1589 - 1597 (2009/07/30)
Poly-β-peptides are attractive for biomedical applications because the backbone is similar enough to that of proteins for biocompatibility,but the backbone is sufficiently unnatural that these polymers evade pr oteolytic degradation. Prior investigations
