1174498-45-3Relevant academic research and scientific papers
Unexpected C - O bond formation in Suzuki coupling of 4-chlorothieno[2,3-d] pyrimidines
Perspicace, Enrico,Hesse, Stephanie,Kirsch, Gilbert,Yemloul, Mehdi,Lecomte, Claude
experimental part, p. 459 - 464 (2009/09/28)
(Chemical Equation Presented) Palladium-catalyzed Suzuki reactions were performed on 4-chlorothieno[2,3-d]pyrimidines under classical heating conditions and under microwave irradiation. Some unexpected results were obtained during this study as two kinds of compounds were isolated depending on the conditions used. A careful investigation of experimental details has shown that the expected CAC bond formation occurred when degassed solvents were used (both in classical and microwave heating) whereas an unexpected CAO bond formation happened when solvents were not degassed with argon-bubbling before use.
