117452-24-1

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 117452-35-4 2-Amino-4-(2-chloro-phenyl)-5,7-dioxo-6-phenyl-4,4a,5,6,7,7a-hexahydro-thiopyrano[2,3-c]pyrrole-3-carbonitrile 
• 117452-26-3 6-Amino-4-(2-chloro-phenyl)-3,4-dihydro-2H-thiopyran-3,5-dicarbonitrile 
• 137150-45-9 2-methylthio-6-methyl-4-(o-chlorophenyl)-5-carbamoyl-3-cyano-1,4-dihydropyridine 
• 1456686-56-8 3-(2-chlorophenyl)-2-cyanopropanethioamide 
• 117452-29-6 6-Amino-4-(2-chloro-phenyl)-5-cyano-3,4-dihydro-2H-thiopyran-3-carboxylic acid ethyl ester 
• 117452-32-1 2-Amino-4-(2-chloro-phenyl)-5-nitro-6-phenyl-5,6-dihydro-4H-thiopyran-3-carbonitrile 
• 117452-38-7 2-Amino-4-(2-chloro-phenyl)-5,7-dioxo-6-p-tolyl-4,4a,5,6,7,7a-hexahydro-thiopyrano[2,3-c]pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Multicomponent synthesis and molecular structure of 3-amino-2-aroyl(alkoxycarbonyl, arylcarbamoyl)-4-aryl(hetaryl)-5-arylcarbamoyl-6-methylthieno[2,3-b]pyridines

[Figure not available: see fulltext.] A new, effective method has been developed for the synthesis of functionalized thieno[2,3-b]pyridines by multicomponent condensation reactions of aromatic and heteroaromatic aldehydes, cyanothioacetamide, acetoacetanilides, and alkylating agents containing activated methylene groups. The structures of 3-amino-2-benzoyl-4-(furan-2-yl)-6-methyl-N-phenylthieno[2,3-b]pyridine-5-carboxamide, 3-amino-N2-(4-bromophenyl)-N5-(4-chlorophenyl)-6-methyl-4-(3-methylthiophen-2-yl)thieno[2,3-b]pyridine-2,5-dicarboxamide, and 3-amino- 4-(2-chlorophenyl)-N-(4-chlorophenyl)-6-methyl-2-(4-methylbenzoyl)thieno[2,3-b]pyridine-5-carboxamide were studied by X-ray structural analysis.

New Multicomponent Synthesis of Functionalized Nitriles and Esters of 6-Alkylsulfanyl-1,4-dihydronicotinic Acids

Abstract: The multicomponent condensation of malononitrile, hydrogen sulfide, aryl orhetaryl aldehydes, 1,3-dicarbonyl compounds and alkylating reagents affordedfunctionalized nitriles and esters of 6-alkylsulfanyl-1,4-dihydronicotinicacids, their aromatic analogues and 1,4-dihydrothieno[2,3-b]pyridines.

Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction

This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.

Regioselective reduction of 2-cyanoprop-2-enethioamides with sodium borohydride

Treatment of 2-cyanoprop-2-enethioamides with NaBH4 in EtOH gave C-alkylated cyanothioacetamides in 62-69% yields.