1174520-07-0Relevant articles and documents
Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris
Martin, Jesus,Da Sousa, Thiciana S.,Crespo, Gloria,Palomo, Sara,Gonzalez, Ignacio,Tormo, Jose R.,De La Cruz, Mercedes,Anderson, Matthew,Hill, Russell T.,Vicente, Francisca,Genilloud, Olga,Reyes, Fernando
, p. 387 - 398 (2013/05/09)
A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey's analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
A phenylacetylated peptide, JBIR-96, isolated from Streptomyces sp. RI051-SDHV6
Ueda, Jun-Ya,Izumikawa, Miho,Kozone, Ikuko,Yamamura, Hideki,Hayakawa, Masayuki,Takagi, Motoki,Shin-Ya, Kazuo
experimental part, p. 1344 - 1347 (2011/07/29)
Searching for metabolites from Streptomyces sp. RI051-SDHV6 resulted in the discovery of a novel peptide, JBIR-96 (1). The structure of 1 was established as an N-phenylacetylated pentapeptide involving a cysteic acid and a peptide lactone structure by extensive NMR and MS analyses. In addition, the absolute configuration of 1 was established by Marfey's and modified Mosher's methods. (Chemical Equation Presented).