1174589-29-7Relevant academic research and scientific papers
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
Xin, Botao,Tang, Weifang,Wang, Yue,Lin, Guowu,Liu, Haichun,Jiao, Yu,Zhu, Yong,Yuan, Haoliang,Chen, Yadong,Lu, Tao
, p. 4783 - 4786 (2012/08/13)
β-Carboline family of compounds is a large group of alkaloids widely distributed in nature and exhibits broad-spectrum anti-tumor activities. We designed and synthesized two series of novel 1-carboxamide- and 6-sulfonamide-substituted β-carboline derivatives 7a-p and 12a-b, and their wild type B-Raf kinase inhibitory activities were described. Most compounds showed moderate to excellent inhibitory activities. Among them, 1-carboxamide-6-(N-(3-(dimethylamino)propyl)-sulfamoyl)-β-carboline, 7e exhibited potent activity (IC50 = 1.62 μM), showing the potential for further investigation as a lead compound.
