1174589-90-2Relevant academic research and scientific papers
Piperidine based effective chemosensor for Zn(II) with the formation of binuclear Zn complex having specific Al(III) detection ability in aqueous medium and live cell images
Das, Manik,Koley, Biplab,Das, Uttam Kumar,Bag, Arijit,Laha, Soumik,Chandra Samanta, Bidhan,Choudhuri, Indranil,Bhattacharyya, Nandan,Maity, Tithi
, (2021)
A schiff base chemosensor HL [4-chloro-(((2-(piperidine-1-yl)imino)methyl)phenol], constructed by one step condensation of 2-aminoethyl piperidine and 5- Chloro Salicylaldehyde is illustrated to have its usefulness for selective and sensitive detection of Zn(II) among other metal ions in aqueous solution (HEPES buffer) displaying the colour changes from light blue to turquoise under UV light. The specific detection phenomena of Zn (II) is monitored by the remarkable fluorescence enhancement and notable change in NMR spectral data of fluorescence active HL after addition of Zn(II) to it. The impressive high binding constant in 106 orders, determined by electronic spectral titration after introduction of Zn(II) to HL assure the formation of a Zinc complex during sensing phenomena. In order to check whether the nuclearity of the constructed complex can be increased or not fluorescence enhancement phenomenon is further monitored in presence of different bridging ligands and the results display that only in presence of azide a significant enhancement of Zn(II)-HL domain is exposed where as for other bridging ligand the spectra remain unaltered. This observation insists to conduct the reaction between HL and ZnCl2 in presence of sodium azide which lead the formation of a Zn complex [Zn2(HL)2(N3)4] (complex 1) employing azide as the secondary anionic residue instead of bridging. The single crystal structure of the complex unveils the unique protonation of the piperidine N during the crystallization of the dinuclear motif of the complex 1. Furthermore the Zn complex due to the presence of remarkable luminescence property have been effectively used for selective sensing of Al(III) ion as metalloreceptor in HEPES buffer solution via turn of fluorescence with remarkable fluorescence quenching constant. In aqueous solution, complex 1 induces a 1:2 complex formation with Al(III) ion indicated by Job's plot analysis. The DFT study suggests the formation of bimetal complex during sensing of Al(III) with complex 1 as metalloreceptor. The in vitro cell imaging study gives a authentic hints for in vivo biomedical application of HL as a selective and easy Zn(II) sensor. The two step sensing phenomena of HL and complex 1 is further established by advanced molecular logic gate formation.
