117460-96-5

Basic information

• Product Name: methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate
• Synonyms: methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate
• CAS NO: 117460-96-5
• Molecular Weight: 259.421
• Mol File: 117460-96-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate(117460-96-5)
• EPA Substance Registry System: methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate(117460-96-5)

Safety Data

• Hazardous Substances Data: 117460-96-5(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1367552-62-2 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate 
• 1367552-64-4 (2R,3S,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-3-methylpyrrolidine-1,2-dicarboxylate 
• 1279701-25-5 C₂₁H₃₃NO₅Si 
• 1367553-87-4 C₃₀H₄₀N₄O₅S 
• 1610036-18-4 (2R,3S,4R)-1-benzyl 2-methyl 4-hydroxy-3-methylpyrrolidine-1,2-dicarboxylate 
• 1236784-04-5 Cbz-MeVal-(4R-OTBS)Pro-OMe 

Relevant articles and documents

Amphiphilic immobilized diphenylprolinol alkyl ether catalyst on PS-PEG resin

Diphenylprolinol silyl ether is a widely used organocatalyst, and its immobilization on a solid support was investigated for the easy recycling and reuse of this catalyst. Because a silyl ether bond of the catalyst is weak, its alkyl ether was attached to polymers such as a polyquinoxaline-based polymer, a polystyrene polymer (PS) resin, and a polystyrenepoly(ethylene glycol) graft copolymer (PS-PEG) resin. Although a polymer-supported organocatalyst generally decreases its reactivity compared with the monomer catalyst, diphenylprolinol anthrylmethyl ether supported on PS-PEG was found to be a reactive organocatalyst; it catalyzed the Michael reaction of an aldehyde and a nitroalkene in water without an organic solvent being present, with excellent diastereo- and enantioselectivities.

PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES

The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.