1174642-41-1Relevant academic research and scientific papers
Chemoselective Ullmann coupling at room temperature: A facile access to 2-aminobenzo[b] thiophenes
Janni, Manojkumar,Thirupathi, Annaram,Arora, Sahil,Peruncheralathan
, p. 8439 - 8442 (2017)
Various functionalized 2-aminobenzo[b]thiophenes have been synthesized at room temperature by the Ullmann coupling reaction for the first time. The enantiospecific coupling reaction has been further demonstrated without loss of optical purity. The newly synthesized 2-anilino-3-cyano-benzo[b]thiophenes are transformed into 11-amino-benzothieno[2,3-b]quinolines in the presence of triflic acid.
2,3-Difunctionalized Benzo[ b]thiophene Scaffolds Possessing Potent Antiangiogenic Properties
Singh, Himalaya,Thirupathi, Annaram,Das, Bishwaprava,Janni, Manojkumar,Kumari, Renu,Singh, Sandeep,Rashid, Mamunur,Wahajuddin, Mohammad,Balamurali, Musuvathi Motilal,Jagavelu, Kumaravelu,Peruncheralathan, Saravanan
, p. 120 - 134 (2022/01/03)
A new class of 2-anilino-3-cyanobenzo[b]thiophenes (2,3-ACBTs) was studied for its antiangiogenic activity for the first time. One of the 2,3-ACBTs inhibited tubulogenesis in a dose-dependent manner without any toxicity. The 2,3-ACBTs significantly reduced neovascularization in both ex vivo and in vivo angiogenic assays without affecting the proliferation of endothelial cells. Neovascularization was limited through reduced phosphorylation of Akt/Src and depolymerization of f-actin and β-tubulin filaments, resulting in reduced migration of cells. In addition, the 2,3-ACBT compound disrupted the preformed angiogenic tubules, and docking/competitive binding studies showed that it binds to VEGFR2. Compound 2,3-ACBT had good stability and intramuscular profile, translating in suppressing the tumor angiogenesis induced in a xenograft model. Overall, the present study suggests that 2,3-ACBT arrests angiogenesis by regulating the Akt/Src signaling pathway and deranging cytoskeletal filaments of endothelial cells.
Nickel catalyzed site selective C-H functionalization of α-aryl-thioamides
Bandyopadhyay, Debashruti,Thirupathi, Annaram,Dhage, Nagsen Munjaji,Mohanta, Nirmala,Peruncheralathan
, p. 6405 - 6409 (2018/09/25)
A catalytic site selective intramolecular C-S bond forming reaction is demonstrated for the first time. The C-H bond functionalization of α-aryl-thioacetanilides was efficiently catalyzed by 2 mol% NiBr2, resulting in valuable 2-aminobenzo[b]thiophenes in moderate to good yields. Furthermore, the selective sp2 C-H bond functionalization over sp3 is exemplified.
