1174650-79-3Relevant academic research and scientific papers
UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF
-
Page/Page column 68, (2010/01/07)
Disclosed are dispyrin analogue compounds useful as H3 receptor activity modulators, methods of making same, pharmaceutical compositions comprising same, and methods of treating neurological and psychiatric disorders associated with histamine H3 receptor activity using same. In one aspect, the disclosed analogues can have a structure represented by a formula: (I), This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin
Phillip Kennedy,Jeffrey Conn,Lindsley, Craig W.
scheme or table, p. 3204 - 3208 (2010/03/31)
This Letter describes the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin, and the resulting SAR of H3 antagonism. Multiple rounds of iterative parallel synthesis improved human H3 I
