117468-08-3

Upstream product

• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 108909-88-2 Trans-2-fluorocyclooct-5-en-1-ol 
• 5259-72-3 cyclo-octa-1,5-diene 
• 93953-49-2 trans-8-iodo-cyclooct-4-en-1-yl acetate 

Downstream Products

• 286-62-4 Cyclooctene oxide 
• 29417-19-4 trans-trans-2,5-di-iodo-9-oxabicyclo<4.2.1>nonane 
• 10299-46-4 endo,endo-2,6-diiodo-9-oxa-bicyclo[3.3.1]nonane 
• 51097-60-0 (Z)-oct-4-enedial 
• 4277-34-3 (Z)-cyclooct-4-enol 
• 108909-88-2 Trans-2-fluorocyclooct-5-en-1-ol 
• 112348-22-8 (Z)-8-(benzylamino)cyclooct-4-enol 
• 292-64-8 Cyclooctan 
• 31598-91-1 rac-(Z)-cyclooct-5-en-1,2-diol 
• 28399-88-4 4,5-Epoxycyclooctanon 
• 105309-55-5 9-Benzyl-3-(2-oxo-ethyl)-9-aza-bicyclo[4.2.1]nonane-2-carbaldehyde 
• 39770-04-2 8-nonen-1-al 
• 123836-25-9 (+/-)-8-phenyl-4-cycloocten-1-one 

Relevant academic research and scientific papers

Molybdenum-MCM-41 silica as heterogeneous catalyst for olefin epoxidation

MCM-41-supported molybdenum/bis-dithiocarbamate complex can be efficiently utilized, after treatment with tert-butylhydroperoxide (TBHP), for the epoxidation of alkenes under solventless conditions. The treatment with TBHP allows the formation of the real catalyst through oxidative decomposition of the complex affording well dispersed Mo(VI) species grafted onto the silica surface through the silanol groups. Experimental results, catalytic efficiency and spectroscopy data, allow to advance some hypotheses on the molybdenum-grafted catalyst formation. The grafted catalyst can be reused several times in the model epoxidation of cyclohexene affording the epoxide with very good yield; only during the first run a modest molybdenum leaching is observed. Both cyclic and linear alkenes can be epoxidized in good to excellent yields and selectivities.

Tunable Electrochemical and Catalytic Features of BIAN- and BIAO-Derived Ruthenium Complexes

This article deals with a class of ruthenium-BIAN-derived complexes, [RuII(tpm)(R-BIAN)Cl]ClO4 (tpm = tris(1-pyrazolyl)methane, R-BIAN = bis(arylimino)acenaphthene, R = 4-OMe ([1a]ClO4), 4-F ([1b]ClO4), 4-Cl ([1c]ClO4), 4-NO2 ([1d]ClO4)) and [RuII(tpm)(OMe-BIAN)H2O]2+ ([3a](ClO4)2). The R-BIAN framework with R = H, however, leads to the selective formation of partially hydrolyzed BIAO ([N-(phenyl)imino]acenapthenone)-derived complex [RuII(tpm)(BIAO)Cl]ClO4 ([2]ClO4). The redox-sensitive bond parameters involving -N=C-C=N- or -Ni=C-C=O of BIAN or BIAO in the crystals of representative [1a]ClO4, [3a](PF6)2, or [2]ClO4 establish its unreduced form. The chloro derivatives 1a+-1d+ and 2+ exhibit one oxidation and successive reduction processes in CH3CN within the potential limit of ±2.0 V versus SCE, and the redox potentials follow the order 1a+ + + + ≈ 2+. The electronic structural aspects of 1an-1dn and 2n (n = +2, +1, 0, -1, -2, -3) have been assessed by UV-vis and EPR spectroelectrochemistry, DFT-calculated MO compositions, and Mulliken spin density distributions in paramagnetic intermediate states which reveal metal-based (RuII → RuIII) oxidation and primarily BIAN- or BIAO-based successive reduction processes. The aqua complex 3a2+ undergoes two proton-coupled redox processes at 0.56 and 0.85 V versus SCE in phosphate buffer (pH 7) corresponding to {RuII-H2O}/{RuIII-OH} and {RuIII-OH}/{RuIV=O}, respectively. The chloro (1a+-1d+) and aqua (3a2+) derivatives are found to be equally active in functioning as efficient precatalysts toward the epoxidation of a wide variety of alkenes in the presence of PhI(OAc)2 as oxidant in CH2Cl2 at 298 K, though the analogous 2+ remains virtually inactive. The detailed experimental analysis with the representative precatalyst 1a+ suggests the involvement of the active {RuIV=O} species in the catalytic cycle, and the reaction proceeds through the radical mechanism, as also supported by the DFT calculations.

Design and synthesis of violet odorants with bicyclo[6.4.0]dodecene and bicyclo[5.4.0]undecene skeletons

The Diels-Alder reaction of 1,2-bis(methylene)cyclooctane (13), 4- methylenespiro[2.7]decane (29), 4-methylenespiro[2.6]nonane (40) and 4- methylenespiro[2.7]dec-8-ene (46) with different α,β-unsaturated carbonyl compounds afforded various derivatives 16, 18, 20, 22, 24, 26, 32, 36, 38, 41, 42 and 47 of a molecular-modeled lead compound 9. These less flexible β- ionone-mimics with bicyclo[6.4.0]dodecene and bicyclo[5.4.0]undecene skeletons possess interesting fruity-woody-floral odor notes and provide insight into the structure-odor correlation of violet odorants. 5-(2- Methylcycloalk-1-en-1-yl)hex-3-en-2-ones (e.g. 35) were identified as byproducts of the Rh(I)-catalyzed reactions of the vinylcyclopropanes 29 and 40.

Methyltrioxorhenium-catalyzed epoxidations in ionic liquids

Alkenes and allylic alcohols have been epoxidized in an ambient- temperature ionic liquid for the first time using methyltrioxorhenium (MTO) and urea hydrogen peroxide; excellent conversions and selectivities for the epoxides of a wide number of substrates were observed.

Co(ii) complexes loaded into metal-organic frameworks as efficient heterogeneous catalysts for aerobic epoxidation of olefins

A series of efficient cobalt(ii)-anchored Cr-MOF (Cr-MIL-101-NH2) catalysts, such as Co(ii)@Cr-MIL-101-Sal, Co(ii)@Cr-MIL-101-P2I and Co(ii)@Cr-MIL-101-P3I, have been successfully synthesized by one-pot modification of the terminal amino group with salicylaldehyde, pyridine-2-aldehyde or pyridine-3-aldehyde and anchoring of Co(ii) ions into the mesoporous Cr-MOF supports. The Co(ii)@Cr-MIL-101-P2I catalyst exhibited high catalytic performance for epoxidation of olefins with air as an oxidant due to the nitrogen atom in the pyridine ring as a strong electron-withdrawing substituent, high dispersion of Co(ii) species and high surface area for sufficient contact between the substrate and active sites. The strong coordination interaction between the Co(ii) ions and chelating groups in the Co(ii)@Cr-MIL-101-P2I catalyst guaranteed the excellent recycling performance. Furthermore, the synthesized Co(ii)@Cr-MIL-101-P2I catalyst realized its general applicability towards various olefins, such as cyclic olefins, tri-substituted olefins, aliphatic olefins and aromatic olefins.

New multiblock copolymers of norbornene and 5-hydroxycyclooctene

Cross-metathesis of 5-hydroxycyclooctene and norbornene homopolymers affords the multiblock copolymer possessing a broad range in the degree of blockiness (from 0.03 to 1).

Chemoselective epoxidation of dienes using polymer-supported manganese porphyrin catalysts

Manganese porphyrin catalysts supported on different polymer resins were assessed in the selective epoxidation of three dienes. The recyclability of the catalysts was examined.

Synthesis of pendent functionalized cyclotriphosphazene polyoctenamers: Amphiphilic lithium ion conductive materials

The synthesis of novel polyoctenamers with pendent functionalized cyclotriphosphazenes as amphiphilic lithium ion conductive membranes is described. Cyclotriphosphazene monomers were functionalized with one cycloocteneoxy substituent per ring. Two different types of monomer units, one with oligoethyleneoxy cation coordination side groups and the other with hydrophobic fluoroalkoxy side groups, were then prepared. The syntheses of these monomers, their ring-opening metathesis copolymerization, and the characteristics of the resultant polymers are discussed, with an emphasis on the dependence of ionic conductivity and hydrophobicity on polymer composition.

MONOACYLGLYCEROL LIPASE MODULATORS

Fused and bridged compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: (I) wherein R1a, R1b, R2, and R3, are defined herein.

Monoacylglycerol Lipase Modulators

Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R2, R3 R4, R5 and R6 are defined herein.