1174685-39-2Relevant academic research and scientific papers
General and efficient synthetic approach to novel tricyclic spiroketones
Chu, Guo-Hua,Le Bourdonnec, Bertrand,Gu, Minghua,Saeui, Christopher T.,Dolle, Roland E.
experimental part, p. 5161 - 5167 (2009/12/09)
A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.
