1174712-65-2Relevant academic research and scientific papers
K2S2O8 -Activated Friedel-Crafts Type Alkylation of Indoles with α-Amido Sulfones
Wu, Xiaoyan,Xue, Lu,Luo, Shilong,Jia, Shiqi,Ao, Jun,Qin, Wenling
, p. 5017 - 5024 (2017)
A K 2 S 2 O 8 -activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by using Lewis acid, clay, and resin as catalyst for this Friedel-Crafts type alkylation of indoles with α-amido sulfones. The formed product bears a versatile transformable sulfone group and an amino group. The reaction condition is tolerant to a wide range of substrates, including a series of indoles with electron-withdrawing and electron-donating groups at different positions. Moreover, a variety of α-substituted phenylamido sulfones and some α-aliphatic amido sulfones also give the desired products in modest yield. Furthermore, a preliminary mechanism study was performed and the plausible reaction mechanism is discussed.
