117474-82-5Relevant academic research and scientific papers
Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
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, (2008/06/13)
This invention is directed to compounds having the formula: STR1 wherein: A represents an aromatic or heterocyclic ring having two of its carbon atoms held mutually with the oxazepine, thiazepine or diazepine moiety selected from the group consisting of benzene, naphthalene, a quinoline, a pyridine in any of its four positions, any of which rings are optionally substituted by one or two Y radicals selected from the group consisting of halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, lower acylamino, trilfuoromethyl, phenyl or phenyl substituted by one to three Y' groups selected from halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracylamino or trifluoromethyl, E is selected from oxygen, sulfur or STR2 B is selected from the group consisting of loweralkyl, cycloalkyl or phenyl-loweralkyl wherein phenyl is optionally substituted by one or two radicals selected from halo, loweralkyl, loweralkoxy, nitro or trifuoromethyl, N is 1 or 2, R4 and R5 are selected from hydrogen or loweralkyl (1-5 C), X is halogen selected from chlorine, bromine, cyano or 1-phthalimido, the optical isomers thereof and the acid addition salts thereof. These compounds are valuable intermediates in the preparation of compounds having antihistaminic utility.
Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
-
, (2008/06/13)
Aromatic azepinones and thiones having the formula STR1 wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or STR2 n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen-containing radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; Y is halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracetylamino, trifluoromethyl, phenyl or phenyl substituted by one to three Y' radicals selected from halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracylamino or trifluoromethyl; and having antihistaminic utility, a process for the preparation thereof and chemical intermediates therefor are disclosed.
