1174749-33-7

Basic information

• Product Name: N-[3-(4-{4-(3-(3-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
• Synonyms: N-[3-(4-{4-(3-(3-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
• CAS NO: 1174749-33-7
• Molecular Weight: 577.535
• Mol File: 1174749-33-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[3-(4-{4-(3-(3-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(4-{4-(3-(3-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide(1174749-33-7)
• EPA Substance Registry System: N-[3-(4-{4-(3-(3-trifluoromethyl-phenyl)-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl}-3-fluoro-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide(1174749-33-7)

Safety Data

• Hazardous Substances Data: 1174749-33-7(Hazardous Substances Data)

Upstream product

• 708274-24-2 3-[3-(trifluoromethyl)phenyl]-4,5-dihydroisoxazole-5-carboxylic acid 
• 154590-66-6 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant articles and documents

Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial

A series of (5S) N-(3-{3-fluoro-4-[4-(3-aryl-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide(6a-o) were synthesized and their in vitro antibacterial activity against various resistant Gram-positive and Gram-negative bacteria were evaluated. Most of the synthesized compounds showed 2 to 10 fold lower MIC values compared to linezolid against Staphylococcus aureus ATCC 25923, ATCC 70069, ATCC 29213, Bacillus cereus MTCC 430, Enterococcus faecalis MTCC439, Klebsiella pneumoniae ATCC 27736, and Streptococcus pyogens.