117480-98-5Relevant academic research and scientific papers
A facile one-pot synthesis of 2-pyrazolyl-4-aryl-thiazoles in a threecomponent reaction
Nalajam, Guravaiah,Vedula, Rajeswar Rao
experimental part, p. 195 - 197 (2009/08/07)
A one-pot multi-component reaction of phenacylbromide, thiosemicarbazide and acetyl acetone or ethyl acetoacetate is described for the preparation of the title compounds. The key features of this methodology are its operational simplicity, mild reaction conditions, and good yields.
Reaction of 4-Aryl-2-hydrazinothiazoles with Ethyl Acetoacetate: A Reinvestigation
Singh, S. P.,Sehgal, Subhash,Diwakar, P.,Vaid, R. K.
, p. 573 - 575 (2007/10/02)
The reaction of 4-aryl-2-hydrazinothiazoles (1a,b) with ethyl acetoacetate (2) affords 1-(4'-aryl 2'-thiazolyl)-3-methylpyrazol-5-ols (3a,b) rather than 3-arylthiazolotriazepin-5-ones (4a,b),as previously reported.The correct structural assignment is based on an alternate synthesis involving reaction of phenacyl bromides (6) and 3-methylpyrazol-5-ol-1-thiocarboxamide (7).The keto/enol tautomerism of 3 has been investigated using PMR spectroscopy.
