117480-99-6

Upstream product

• 26049-70-7 2-Hydrazino-4-(4-nitrophenyl)thiazole 
• 141-97-9 ethyl acetoacetate 
• 117481-01-3 ethyl 3-[{4-(4-nitrophenyl)thiazol-2-yl}hydrazono]butanoate 
• 99-81-0 4-Nitrophenacyl bromide 
• 146120-04-9 1-[amino(thioxo)methyl]-5-hydroxy-3-methyl-1H-pyrazole 

Relevant academic research and scientific papers

Reaction of 4-Aryl-2-hydrazinothiazoles with Ethyl Acetoacetate: A Reinvestigation

The reaction of 4-aryl-2-hydrazinothiazoles (1a,b) with ethyl acetoacetate (2) affords 1-(4'-aryl 2'-thiazolyl)-3-methylpyrazol-5-ols (3a,b) rather than 3-arylthiazolotriazepin-5-ones (4a,b),as previously reported.The correct structural assignment is based on an alternate synthesis involving reaction of phenacyl bromides (6) and 3-methylpyrazol-5-ol-1-thiocarboxamide (7).The keto/enol tautomerism of 3 has been investigated using PMR spectroscopy.