117482-14-1Relevant academic research and scientific papers
Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones
Yuan, Jing,Liu, Chong,Chen, Yan,Zhang, Zhenfeng,Yan, Deyue,Zhang, Wanbin
, p. 269 - 277 (2018/12/05)
The intramolecular hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of additional substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asymmetric version has not been considered possible due to problems associated with the racemization of the products. We have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramolecular hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asymmetric variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.
Cobalt-Catalyzed Cyclocarbonylation of Acetylenes under Water Gas Shift Conditions. Selective Synthesis of Indan-1-ones
Doyama, Kazuo,Fujiwara, Keisuke,Joh, Takashi,Maeshima, Kazuo,Takahashi, Shigetoshi
, p. 901 - 904 (2007/10/02)
Carbonylation of phenylacetylene derivatives by a cobalt catalyst under water gas shift conditions affords indan-1-ones in satisfactory yields.
