1174936-23-2Relevant academic research and scientific papers
Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists
Moriya, Minoru,Kishino, Hiroyuki,Sakuraba, Shunji,Sakamoto, Toshihiro,Suga, Takuya,Takahashi, Hidekazu,Suzuki, Takao,Ito, Masahiko,Ito, Junko,Moriya, Ryuichi,Takenaga, Norihiro,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro
scheme or table, p. 3568 - 3572 (2010/03/24)
A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modification of the 2- and 5-positions led to improvement in potency and intrinsic clearance. Compound 25 exhibited good p
