1175013-61-2

Basic information

• Product Name: C₂₅H₂₂F₂N₄O₂
• CAS NO: 1175013-61-2
• Molecular Weight: 448.472
• Mol File: 1175013-61-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₂F₂N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₂F₂N₄O₂(1175013-61-2)
• EPA Substance Registry System: C₂₅H₂₂F₂N₄O₂(1175013-61-2)

Safety Data

• Hazardous Substances Data: 1175013-61-2(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 900512-26-7 3,5-difluoro-2-methyl-phenol 
• 1175014-69-3 4-(2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1175014-68-2 2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid 
• 1175014-67-1 2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde 
• 1175014-66-0 1-phenyl-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one 
• 514182-79-7 1-phenyl-1H-pyrrolo[3,2-b]pyridine 
• 272-49-1 1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors

The control of hypertension and associated cardiovascular risk factors is possible by selective inhibition of the aspartyl protease renin due to its unique position in the renin-angiotensin system. Starting from a previously disclosed series of potent and nonchiral indole-3-carboxamides, we further explored this motif by structure-based drug design guided by X-ray crystallography in combination with efficient parallel synthesis. This resulted in the discovery of 4- or 6-azaindole derivatives with remarkable potency for renin inhibition. The best compound from these series showed an IC50 value of 1.3 nM.