1175036-51-7Relevant articles and documents
An efficient scale up process for synthesis of N-arylpiperazines
Ravilla, Lokesh,Venkata Subba Naidu,Nagarajan, Kuppuswamy
supporting information, p. 4541 - 4544 (2015/06/30)
An efficient protocol for the synthesis of various substituted phenylpiperazines was developed using sulfolane as solvent. The protocol was clean, high yielding and products were obtained in high purities (≥99%). It was also fast and convenient, as the final products were precipitated as hydrochloride salts and could be obtained by filtration. Sulfolane, an aprotic, dipolar, high boiling and recoverable solvent was used as a substitute for common organic solvents.