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1175090-79-5

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1175090-79-5 Usage

Chemical compound

2-Amino-N,N-dimethyl-3-phenylpropanamide hydrochloride

Usage

Local anaesthetic, particularly in dentistry

Physical properties

White to off-white crystalline powder, soluble in water and ethanol

Mechanism of action

Blocks transmission of nerve signals, resulting in loss of sensation

Additional properties

Analgesic and anesthetic properties, antiarrhythmic effects

Potential use

Treatment of cardiac arrhythmias

Check Digit Verification of cas no

The CAS Registry Mumber 1175090-79-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,5,0,9 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1175090-79:
(9*1)+(8*1)+(7*7)+(6*5)+(5*0)+(4*9)+(3*0)+(2*7)+(1*9)=155
155 % 10 = 5
So 1175090-79-5 is a valid CAS Registry Number.

1175090-79-5Relevant articles and documents

Highly enantioselective, intermolecular hydroamination of allenyl esters catalyzed by bifunctional phosphinothioureas

Fang, Yuan-Qing,Tadross, Pamela M.,Jacobsen, Eric N.

, p. 17966 - 17968 (2014)

Bifunctional phosphinothiourea catalysts have been developed successfully for the highly regio- and enantioselective γ-hydroamination of allenyl and propargyl esters with N-methoxy carbamate nucleophiles to yield α,β-unsaturated γ-amino acid ester products. In the case of propargyl ester substrates, the reaction proceeds through reversible phosphinothiourea-catalyzed isomerization to the corresponding allenyl ester. The high enantioselectivity of the process is attributed to a cooperative conjugate addition of a thiourea-bound carbamate anion to a vinyl phosphonium ion resulting from covalent activation of the allenyl ester substrate.

Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls

Coombs, Gavin,Sak, Marcus H.,Miller, Scott J.

supporting information, p. 2875 - 2880 (2020/01/24)

We have demonstrated that small, modular, tetrameric peptides featuring the Lewis-basic residue β-dimethylaminoalanine (Dmaa) are capable of atroposelectively coupling naphthols and ester-bearing quinones to yield non-C2-symmetric BINOL-type scaffolds with good yields and enantioselectivity. The study culminates in the asymmetric synthesis of backbone-substituted scaffolds similar to 3,3′-disubstituted BINOLs, such as (R)-TRIP, with good (94:6 e.r.) to excellent (>99.9:0.1 e.r.) enantioselectivity after recrystallization, and a diastereoselective net arylation of the minimally modified nonsteroidal anti-inflammatory drug (NSAID) naproxen.

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

Shen, Peng-Xiang,Hu, Liang,Shao, Qian,Hong, Kai,Yu, Jin-Quan

supporting information, p. 6545 - 6549 (2018/05/23)

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

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